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UID:150b1f6a41b81516cbba1070bc6f3fe9@uk-icn.co.uk
SUMMARY:2023 April Virtual Seminar
DESCRIPTION:Session Chair: Dr Erica Bickerton\, The Pirbright Institute\, a
 nd UK-ICN Co-Lead for Countermeasures and Interventions\n\nDr Nerea Irigoye
 n\, University of Cambridge - Manipulation of the unfolded protein respons
 e as a pharmacological antiviral strategy for coronavirus infection.\nNerea
  is Research Group Leader in the Division of Virology (Department of Pathol
 ogy) at the University of Cambridge. Nerea undertook a PhD in molecular vir
 ology at the Spanish National Biotechnology Centre in Madrid (Spain) where 
 she studied the assembly and maturation of the capsid of the infectious bur
 sal disease virus (IBDV). In October 2010\, she moved to the Department of 
 Pathology in Cambridge to study non-canonical translational mechanisms in c
 oronaviruses and retroviruses under the supervision of Prof Ian Brierley as
  a Sir Henry Wellcome Postdoctoral Fellow (Wellcome Trust). During that per
 iod\, she also applied a technique called ‘ribosome profiling’\, a glob
 al snapshot of translation\, to RNA viruses such as coronaviruses (e.g. MHV
 -A59)\, retroviruses (e.g. MuLV and HIV-1)\, and flaviviruses (e.g. Dengue 
 and Zika viruses).\nIn September 2018\, she established her own research gr
 oup aiming to understand how virus protein translation can play a role in v
 iral pathogenicity and disease with a special focus on virus-host interacti
 ons. Currently\, her model systems are coronaviruses (e.g. MHV-A59 and SARS
 -CoV-2) and flaviviruses (e.g. Zika virus).\nNerea's profile and twitter\n\
 nDr Arinjay Banerjee\, University of Saskatchewan - Lessons learnt from co
 ronavirus-host interactions in wildlife reservoirs and spill over in hosts.
 \n\nShort abstract: Bats perform important ecological roles in our ecosyst
 em. However\, bats are also reservoirs of emerging viruses that have spill
 ed over into humans and agricultural animals to cause severe disease. Thes
 e viruses include Hendra and Nipah paramyxoviruses\, Ebola and Marburg fi
 loviruses\, and coronaviruses that are closely related to severe acute resp
 iratory syndrome coronavirus (SARS-CoV)\, Middle East respiratory syndrome 
 coronavirus (MERS-CoV)\, and the recently emerged SARS-CoV-2. Intriguingly\
 , bats that are naturally or experimentally infected with these viruses do 
 not show clinical signs of disease. Highly pathogenic zoonotic coronaviruse
 s have evolved proteins that can effectively block innate and intrinsic res
 ponses in human cells. In this talk\, we shall explore how coronaviruses in
 teract with innate and intrinsic responses in their wildlife (bat) and spil
 l over (human) hosts. We will discuss lessons learnt from our studies on ba
 t antiviral responses and translational outcomes that will enable us to des
 ign better countermeasures for coronavirus infections in humans.\n\nArinjay
 's profile and twitter.
LOCATION:Online
DTSTAMP:20260514T102246Z
DTSTART:20230427T150000Z
DTEND:20260514T160000Z
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